… Iron acquisition from heme and hemoglobin by a Serratia … role of His 32 and Tyr 75 in heme
uptake and release processes, we have characterized the electronic properties and the iron …

… Disruption of this bond might play a role in the heme release … greatly enhances the efficiency
of heme uptake by HasR, but … in the presence of hemoglobin in an iron-depleted medium. …

… The heme iron is bound by axial coordination with His-32 … cascade, heme uptake, and
apoHasA release requires structural … of 2 ternary complexes HasA∼HasR∼heme, with wild-type …

… HasR but is unable to release heme for signaling and uptake. To … of a hydroxy ligand between
the heme iron and H75 allows the … pestis HasA encodes a Gln at position 32 with the heme …

… regulatory function of heme at key steps during heme uptake … primarily from hemoproteins
such as hemoglobin (Hb), distinct … -transport system HasDEF and released to the extracellular …

… function of heme binding and release to the HasR receptor. … for heme and heme-binding
proteins such as hemoglobin, … to scavenge iron from their host, that is, heme uptake by the …

… linker region between NEAT domains is required to release heme from hemoglobin. …
demonstrated that HasA SM retains its ability to bind heme despite the loss of a single axial ligand (…

… hemophore secretion and its interaction with heme and hem- … to the mechanism involved
in heme capture or release. For … also functions as a heme receptor that allows the uptake of …

… for the oxygen (O 2 ) carrier hemoglobin (Hb). Indeed, … the release of heme, eg protonation
of heme coordinating … pombe, heme uptake is induced under iron starvation, when two iron-…

… extracellular haem-uptake proteins, which acquire haem as … -binding domain results in the
release of mature HmuY into … HasA coordinates to the haem iron by two axial ligands His32 (…