Background: Despite the well known inflammatory effects of tumour necrosis factor α (TNF),
the mechanism of TNF‐mediated lung injury following ischaemia–reperfusion (I/R) is still
unclear. In this study, the role of TNF in the development of acute lung injury following
intestinal I/R was investigated. Methods: Male Wistar rats underwent either sham operation
(n= 10), 1 h of superior mesenteric artery occlusion and 2 h of reperfusion (I/R, n= 10), or
pretreatment with anti‐TNF polyclonal antibody 2 mg/kg and I/R (n= 6). Lung injury was …

Background Despite the well known inflammatory effects of tumour necrosis factor (TNF), the
mechanism of TNF‐mediated lung injury following ischaemia–reperfusion (IR) is still
unclear. In this study, the role of TNF in the development of acute lung injury following
intestinal IR was investigated. Methods Male Wistar rats underwent either sham operation
(n= 10) or 1 h of superior mesenteric artery occlusion and 2 h of reperfusion (IR; n= 10) or
pretreatment with anti‐TNF polyclonal antibody 2 mg kg− 1 and IR (n= 6). Lung injury was …