Role of ventral medial prefrontal cortex in incubation of cocaine craving
Cue-induced drug-seeking in rodents progressively increases after withdrawal from cocaine,
suggesting that cue-induced cocaine craving incubates over time. Here, we explored the
role of the medial prefrontal cortex (mPFC, a brain area previously implicated in cue-induced
cocaine seeking) in this incubation. We trained rats to self-administer cocaine for 10days
(6h/day, infusions were paired with a tone–light cue), and then assessed after 1 or 30
withdrawal days the effect of exposure to cocaine cues on lever presses in extinction tests …
suggesting that cue-induced cocaine craving incubates over time. Here, we explored the
role of the medial prefrontal cortex (mPFC, a brain area previously implicated in cue-induced
cocaine seeking) in this incubation. We trained rats to self-administer cocaine for 10days
(6h/day, infusions were paired with a tone–light cue), and then assessed after 1 or 30
withdrawal days the effect of exposure to cocaine cues on lever presses in extinction tests …
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