[HTML][HTML] Role of vertebrate GAGA associated factor (vGAF) in early development of zebrafish
Homeotic genes and their genomic organization show remarkable conservation across
bilaterians. Consequently, the regulatory mechanisms, which control hox gene expression,
are also highly conserved. The crucial presence of conserved GA rich motifs between Hox
genes has been previously observed but what factor binds to these is still unknown.
Previously we have reported that the vertebrate homologue of Drosophila Trl-GAF
preferentially binds to GA rich regions in Evx2-hoxd13 intergenic region of vertebrate HoxD …
bilaterians. Consequently, the regulatory mechanisms, which control hox gene expression,
are also highly conserved. The crucial presence of conserved GA rich motifs between Hox
genes has been previously observed but what factor binds to these is still unknown.
Previously we have reported that the vertebrate homologue of Drosophila Trl-GAF
preferentially binds to GA rich regions in Evx2-hoxd13 intergenic region of vertebrate HoxD …
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