[HTML][HTML] Roles of neutrophil gelatinase-associated lipocalin (NGAL) in human cancer

S Candido, R Maestro, J Polesel, A Catania, F Maira… - Oncotarget, 2014 - ncbi.nlm.nih.gov
S Candido, R Maestro, J Polesel, A Catania, F Maira, SS Signorelli, JA McCubrey, M Libra
Oncotarget, 2014ncbi.nlm.nih.gov
Cancer remains one of the major cause of death in the Western world. Although, it has been
demonstrated that new therapies can improve the outcome of cancer patients, still many
patients relapse after treatment. Therefore, there is a need to identify novel factors involved
in cancer development and/or progression. Recently, neutrophil gelatinase-associated
lipocalin (NGAL) has been suggested as a key player in different cancer types. Its oncogenic
effect may be related to the complex NGAL/MMP-9. In the present study, NGAL was …
Abstract
Cancer remains one of the major cause of death in the Western world. Although, it has been demonstrated that new therapies can improve the outcome of cancer patients, still many patients relapse after treatment. Therefore, there is a need to identify novel factors involved in cancer development and/or progression. Recently, neutrophil gelatinase-associated lipocalin (NGAL) has been suggested as a key player in different cancer types. Its oncogenic effect may be related to the complex NGAL/MMP-9. In the present study, NGAL was analyzed at both transcript and protein levels in different cancer types by analysing 38 public available microarray datasets and the Human Protein Atlas tool.
ncbi.nlm.nih.gov
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