Ruthenium (II)-Catalyzed direct C7-selective amidation of indoles with dioxazolones at room temperature
Y Sheng, J Zhou, Y Gao, B Duan, Y Wang… - The Journal of …, 2021 - ACS Publications
Y Sheng, J Zhou, Y Gao, B Duan, Y Wang, A Samorodov, G Liang, Q Zhao, Z Song
The Journal of Organic Chemistry, 2021•ACS PublicationsA protocol for the preparation of 7-amido indoles via regioselective C–H bond
functionalization has been first accomplished under Ru (II) catalysis. Indole derivatives and
4-aryl/heteroaryl/benzyl/alkyl dioxzaolines containing various substituents were applicable
for this transformation, readily providing the amidated indoles in moderate to good yields.
This novel process has many advantages, including good compatibility with diverse
functional groups, broad substrate scopes, and mild reaction conditions. Deuteration studies …
functionalization has been first accomplished under Ru (II) catalysis. Indole derivatives and
4-aryl/heteroaryl/benzyl/alkyl dioxzaolines containing various substituents were applicable
for this transformation, readily providing the amidated indoles in moderate to good yields.
This novel process has many advantages, including good compatibility with diverse
functional groups, broad substrate scopes, and mild reaction conditions. Deuteration studies …
A protocol for the preparation of 7-amido indoles via regioselective C–H bond functionalization has been first accomplished under Ru(II) catalysis. Indole derivatives and 4-aryl/heteroaryl/benzyl/alkyl dioxzaolines containing various substituents were applicable for this transformation, readily providing the amidated indoles in moderate to good yields. This novel process has many advantages, including good compatibility with diverse functional groups, broad substrate scopes, and mild reaction conditions. Deuteration studies and control experiments have been performed to understand the mechanism of this transformation.
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