SARS-CoV-2 Spike Targets USP33-IRF9 Axis via Exosomal miR-148a to Activate Human Microglia
R Mishra, AC Banerjea - Frontiers in immunology, 2021 - frontiersin.org
SARS-CoV-2, the novel coronavirus infection has consistently shown an association with
neurological anomalies in patients, in addition to its usual respiratory distress syndrome.
Multi-organ dysfunctions including neurological sequelae during COVID-19 persist even
after declining viral load. We propose that SARS-CoV-2 gene product, Spike, is able to
modify the host exosomal cargo, which gets transported to distant uninfected tissues and
organs and can initiate a catastrophic immune cascade within Central Nervous System …
neurological anomalies in patients, in addition to its usual respiratory distress syndrome.
Multi-organ dysfunctions including neurological sequelae during COVID-19 persist even
after declining viral load. We propose that SARS-CoV-2 gene product, Spike, is able to
modify the host exosomal cargo, which gets transported to distant uninfected tissues and
organs and can initiate a catastrophic immune cascade within Central Nervous System …
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