… of SNAT7 in macropinocytosis mediated mTORC1 activation, we generated SNAT7 KO MIA
PaCa-2 cells via … We starved wild-type and SNAT7 KO cells of amino acids, stimulated them …

… SNAT7 is required for nutrition of cancer cells in a low free-glutamine environment, when
macropinocytosis … the levels of other amino acids, to mTORC1 (16). The presence of SNAT9 in …

… , it is regulated at mRNA and protein levels by mTORC1 and … of amino acids, from 461 of
SNAT7 to 505 of SNAT2, with … cytoskeletal reorganization linked to macropinocytosis. 490 This …

… regulate mTORC1 by promoting its translocation there, a key … signaling activates mTORC1
via the MAP Kinase Erk and its … inhibits mTORC1 through the induction of p53 target genes, …

… (macropinocytosis) to reactivate the mTORC1 pathway even when extracellular AAs are
scarce. Indeed, SLC38A9 is required for macropinocytosis of albumin to activate mTORC1 and …

… SLC38A9 mediates the transport, in an arginine-regulated fashion, of many … mTORC1
senses through the cytosolic Sestrin proteins. SLC38A9 is necessary for leucine generated via …

… SNAT7 is critical to use BSA as a source of glutamine … Because of insufficient blood supply,
they use macropinocytosis to … It is regulated by mTORC1 by phosphorylation. It is active when …

… the cytosol by the transporter SNAT7 on the lysosomal membrane. … uptaking extracellular
proteins through macropinocytosis; ② by … mTORC1, in turn, regulates the transcription of genes …

… amino-terminal region A component of the lysosomal amino acid sensing machinery that
controls mTORC1 SNAT7 regulates mTORC1 via macropinocytosis Tumor [[20, 23, 25]] …

… SNAT7 regulates mTORC1-dependent macropinocytosis and … through macropinocytosis is
critical for SNAT7-mTORC1 … ” signal and is internalized through P2Y 4 receptors expressed …