SOD-Like activity of copper (II) containing metallopeptides branched by 2, 3-diaminopropionic acid: What the N-termini elevate, the C-terminus ruins
Ł Szyrwiel, M Shimura, B Setner, Z Szewczuk… - International Journal of …, 2019 - Springer
International Journal of Peptide Research and Therapeutics, 2019•Springer
Relations between structural modifiactions and SOD-like activity of four branched Cu II-
metallopeptides based on l-2, 3-diaminopropionic acid are reported. The IC 50 values
(McCord–Fridovich method) illustrate that enhanced SOD-like activity is warranted by
exclusive N-terminal His localization that surmounts the driving force by the Cu II/I formal
potential.
metallopeptides based on l-2, 3-diaminopropionic acid are reported. The IC 50 values
(McCord–Fridovich method) illustrate that enhanced SOD-like activity is warranted by
exclusive N-terminal His localization that surmounts the driving force by the Cu II/I formal
potential.
Abstract
Relations between structural modifiactions and SOD-like activity of four branched CuII-metallopeptides based on l-2,3-diaminopropionic acid are reported. The IC50 values (McCord–Fridovich method) illustrate that enhanced SOD-like activity is warranted by exclusive N-terminal His localization that surmounts the driving force by the CuII/I formal potential.
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