SP7: From bone development to skeletal disease
JS Wang, N Tokavanich, MN Wein - Current osteoporosis reports, 2023 - Springer
JS Wang, N Tokavanich, MN Wein
Current osteoporosis reports, 2023•SpringerAbstract Purpose of Review The purpose of this review is to summarize the different roles of
the transcription factor SP7 in regulating bone formation and remodeling, discuss current
studies in investigating the causal relationship between SP7 mutations and human skeletal
disease, and highlight potential therapeutic treatments that targeting SP7 and the gene
networks that it controls. Recent Findings Cell-type and stage-specific functions of SP7 have
been identified during bone formation and remodeling. Normal bone development regulated …
the transcription factor SP7 in regulating bone formation and remodeling, discuss current
studies in investigating the causal relationship between SP7 mutations and human skeletal
disease, and highlight potential therapeutic treatments that targeting SP7 and the gene
networks that it controls. Recent Findings Cell-type and stage-specific functions of SP7 have
been identified during bone formation and remodeling. Normal bone development regulated …
Purpose of Review
The purpose of this review is to summarize the different roles of the transcription factor SP7 in regulating bone formation and remodeling, discuss current studies in investigating the causal relationship between SP7 mutations and human skeletal disease, and highlight potential therapeutic treatments that targeting SP7 and the gene networks that it controls.
Recent Findings
Cell-type and stage-specific functions of SP7 have been identified during bone formation and remodeling. Normal bone development regulated by SP7 is strongly associated with human bone health. Dysfunction of SP7 results in common or rare skeletal diseases, including osteoporosis and osteogenesis imperfecta with different inheritance patterns. SP7-associated signaling pathways, SP7-dependent target genes, and epigenetic regulations of SP7 serve as new therapeutic targets in the treatment of skeletal disorders.
Summary
This review addresses the importance of SP7-regulated bone development in studying bone health and skeletal disease. Recent advances in whole genome and exome sequencing, GWAS, multi-omics, and CRISPR-mediated activation and inhibition have provided the approaches to investigate the gene-regulatory networks controlled by SP7 in bone and the therapeutic targets to treat skeletal disease.
Springer
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