Hepatocellular carcinoma (HCC) is the fifth most common solid tumor in the world and the
third leading cause of cancer-associated deaths. A Sleeping Beauty-mediated transposon
mutagenesis screen previously identified mutations that cooperate with MYC to accelerate
liver tumorigenesis. This revealed a tumor suppressor role for Steroid Receptor Coactivator
2/Nuclear Receptor Coactivator 2 (Src-2/Ncoa2) in liver cancer. In contrast, SRC-2 promotes
survival and metastasis in prostate cancer cells, suggesting a tissue-specific and context …

1. Suresh S, Durakoglugil D, Zhou X, Zhu B, Comerford SA, Xing C, et al.(2017) SRC-2-
mediated coactivation of anti-tumorigenic target genes suppresses MYC-induced liver
cancer. PLoS Genet 13 (3): e1006650. https://doi. org/10.1371/journal. pgen. 1006650
PMID: 28273073