The emergence of Zika virus (ZIKV) as a global health threat has highlighted the unmet need
for ZIKV-specific vaccines and antiviral treatments. ZIKV infects dendritic cells (DC), which
have pivotal functions in activating innate and adaptive antiviral responses; however, the
mechanisms by which DC function is subverted to establish ZIKV infection are unclear. Here
we develop a genomics profiling method that enables discrete analysis of ZIKV-infected
versus neighboring, uninfected primary human DCs to increase the sensitivity and specificity …