STAT4 is required for the generation of Th1 and Th2, but not Th17 immune responses during monophosphoryl lipid A adjuvant activity

S Varikuti, S Oghumu, G Natarajan… - International …, 2016 - academic.oup.com
STAT4 is critical for the production of IFN-γ during the generation of Th1 immune responses.
We investigated the role of STAT4 in mediating Th1-inducing activity of a vaccine adjuvant
monophosphoryl lipid A (MPL-A) using the standard antigen ovalbumin (OVA) in STAT4KO
mice. Our results show that splenocytes from STAT4KO mice displayed lower OVA-specific T-
cell proliferation and IL-2 production compared with wild-type (WT) mice. Further, IFN-γ
production was diminished in STAT4KO-derived splenocytes but the levels of IL-12 and TNF …

STAT4 is required for the generation of Th1 and Th2, but not Th17 immune responses during monophosphoryl lipid A adjuvant activity

S Varikuti, S Oghumu, G Natarajan… - International …, 2018 - academic.oup.com
Corrigendum STAT4 is required for the generation of T 1 and T 2, but not T 17 immune
responses during monophosphoryl lipid Aáad … 17 immune responses during monophosphoryl
lipid Aáadjuvant activity … The authors of the above paper wish to notify the reader that the
following funding information was not included in the original publication of this manuscript: …
以上显示的是最相近的搜索结果。 查看全部搜索结果