In this study, it was aimed to review saccharine’s genotoxicity and carcinogenicity. Saccharine is one of the most common sweeteners like aspartame, acesulfame K, and cyclamates. It is not metabolized in the gastrointestinal (GI) tract and, therefore, does not affect blood insulin levels. Saccharine-300 times sweeter than sucrose-is commonly used in many foods like soft drinks, baked goods, jams, canned fruits, candy, salad dressings, dessert etc. Because saccharine is consumed by millions of people, including children and even fetuses, it takes great public health significance, and great of interest to the public about its safety. Too many studies have been done for the safety of saccharine. In this study, it was reviewed the all literatures between 1975 and 2014 about saccharine’s safety. According to the literature, genotoxicity and carcinogenicity of saccharine is still confusing. So, consumers should be careful to the consumption of this artificial sweetener.