[HTML][HTML] Axonal endoplasmic reticulum Ca2+ content controls release probability in CNS nerve terminals

J de Juan-Sanz, GT Holt, ER Schreiter, F de Juan… - Neuron, 2017 - cell.com
… of ER health is essential for proper control of synaptic function. … ER Ca 2+ influx pathway
mediated by sarco/endoplasmic … We found that application of the potent SERCA inhibitor …

[PDF][PDF] Bid agonist regulates murine hepatocyte proliferation by controlling endoplasmic reticulum calcium homeostasis

…, N Li, WX Ding, W Gao, M Li, X Chen, J Ma… - …, 2010 - Wiley Online Library
… of sarco/endoplasmic reticulum Ca2þ adenosine triphosphatase (SERCA), which is required
… ER calcium release via enhanced InsP3 receptor activity. This biochemical mechanism has …

A novel histone deacetylase 8 (HDAC8)-specific inhibitor PCI-34051 induces apoptosis in T-cell lymphomas

S Balasubramanian, J Ramos, W Luo, M Sirisawad… - Leukemia, 2008 - nature.com
… To verify that the enzymatic activity of PLCγ1 is essential to … Ca 2+ flux from ER by inhibiting
SERCA pumps; 40 however, PCI-34051-induced calcium flux is dependent on PCLγ1 activity

Defective endoplasmic reticulum-mitochondria contacts and bioenergetics in SEPN1-related myopathy

…, E Varone, RN Villar-Quiles, D Pozzer… - Cell Death & …, 2021 - nature.com
… Endoplasmic reticulum (ER) and mitochondria are essential … oxidation of the ATP-dependent
Ca 2+ pump SERCA [16, 17]. … the Krebs cycle, we quantified the activity of its key proteins in …

Presenilins are essential for regulating neurotransmitter release

…, D Zhang, I Dragatsis, TC Südhof, J Shen - Nature, 2009 - nature.com
reticulum Ca 2+ stores by thapsigargin, or blockade of Ca 2+ … role for presenilins in the
activity-dependent regulation of … We thus investigated whether presynaptic activity is impaired …

Role of TRPC channels in store-operated calcium entry

HL Ong, LB de Souza, IS Ambudkar - … entry pathways in non-excitable cells, 2016 - Springer
sarco-endoplasmic reticulum (SERCA) pump blockers like thapsigargin or cyclopiazonic acid
that inhibit Ca 2+ uptake into ER, unmasking a passive Ca 2… channel activity, data need to …

Supralinear Dependence of the IP3 Receptor-to-Mitochondria Local Ca2+ Transfer on the Endoplasmic Reticulum Ca2+ Loading

G Csordás, D Weaver, P Várnai, G Hajnóczky - Contact, 2024 - journals.sagepub.com
… mean progressively decreasing IP3R channel activities. … that measurement of [Ca 2+ ]
ER was needed. However, to … with the sarco-endoplasmic reticulum Ca 2+ ATP-ase (SERCA) …

Store-operated Ca2+ entry is not required for fertilization-induced Ca2+ signaling in mouse eggs

ML Bernhardt, E Padilla-Banks, P Stein, Y Zhang… - Cell Calcium, 2017 - Elsevier
… initial Ca 2+ release event at fertilization is induced by the activityCa 2+ is subsequently
pumped back into the ER by the action of sarco-endoplasmic reticulum Ca 2+ ATPases (SERCA

Irbit mediates synergy between Ca2+ and cAMP signaling pathways during epithelial transport in mice

…, H Ando, A Mizutani, T Abe, H Kiyonari, G Seki, D Yule… - Gastroenterology, 2013 - Elsevier
… slc26a6, we first increased [Ca 2+ ] i by inhibition of the sarco/endoplasmic reticulum Ca 2+
ATPare (SERCA) pumps with … Moreover, IRBIT is required to maintain basal slc26a6 activity. …

Modulation of T cell metabolism and function through calcium signaling

KM Fracchia, CY Pai, CM Walsh - Frontiers in immunology, 2013 - frontiersin.org
… Importantly, Ca 2+ signaling is essential for T cell activation, … the essential role of Ca 2+
signaling in T cell biology, the Ca 2+ … then impacts Ca 2+ signaling by altering SERCA activity (…