Scanning electron microscopy study on nanoemulsions and solid lipid nanoparticles containing high amounts of ceramides
S Hatziantoniou, G Deli, Y Nikas, C Demetzos… - Micron, 2007 - Elsevier
Ceramides are the most important intercellular lipids of the stratum corneum, regulating the
barrier function of the skin and participating as second signal messenger in stress-induced
apoptosis. The high lipophilicity of ceramides presents a pharmacological problem. In order
to overcome this problem two lipophilic delivery systems were used for the incorporation of
the ceramides:(1) nanoemulsions (NE) and (2) solid lipid nanoparticles (SLN). The influence
of the incorporation of ceramides on the particle shape, size and Polydispersity Index was …
barrier function of the skin and participating as second signal messenger in stress-induced
apoptosis. The high lipophilicity of ceramides presents a pharmacological problem. In order
to overcome this problem two lipophilic delivery systems were used for the incorporation of
the ceramides:(1) nanoemulsions (NE) and (2) solid lipid nanoparticles (SLN). The influence
of the incorporation of ceramides on the particle shape, size and Polydispersity Index was …
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