Secretion of an Argonaute protein by a parasitic nematode and the evolution of its siRNA guides
FWN Chow, G Koutsovoulos… - Nucleic Acids …, 2019 - academic.oup.com
Extracellular RNA has been proposed to mediate communication between cells and
organisms however relatively little is understood regarding how specific sequences are
selected for export. Here, we describe a specific Argonaute protein (exWAGO) that is
secreted in extracellular vesicles (EVs) released by the gastrointestinal nematode
Heligmosomoides bakeri, at multiple copies per EV. Phylogenetic and gene expression
analyses demonstrate exWAGO orthologues are highly conserved and abundantly …
organisms however relatively little is understood regarding how specific sequences are
selected for export. Here, we describe a specific Argonaute protein (exWAGO) that is
secreted in extracellular vesicles (EVs) released by the gastrointestinal nematode
Heligmosomoides bakeri, at multiple copies per EV. Phylogenetic and gene expression
analyses demonstrate exWAGO orthologues are highly conserved and abundantly …
Secretion of an Argonaute protein by a parasitic nematode and the evolution of its siRNA guides.
WNF Chow WangNgai [Chow, G Koutsovoulos… - 2019 - cabidigitallibrary.org
Extracellular RNA has been proposed to mediate communication between cells and
organisms however relatively little is understood regarding how specific sequences are
selected for export. Here, we describe a specific Argonaute protein (exWAGO) that is
secreted in extracellular vesicles (EVs) released by the gastrointestinal nematode
Heligmosomoides bakeri, at multiple copies per EV. Phylogenetic and gene expression
analyses demonstrate exWAGO orthologues are highly conserved and abundantly …
organisms however relatively little is understood regarding how specific sequences are
selected for export. Here, we describe a specific Argonaute protein (exWAGO) that is
secreted in extracellular vesicles (EVs) released by the gastrointestinal nematode
Heligmosomoides bakeri, at multiple copies per EV. Phylogenetic and gene expression
analyses demonstrate exWAGO orthologues are highly conserved and abundantly …
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