This paper conducts a series of centrifuge model tests to evaluate the seismic response characteristics of an anchor-pile-slope system. A real reinforced nonhomogeneous slope that remained stable during the 2008 Wenchuan earthquakes is utilized as the reference prototype. The recorded ground motion near the slope is selected as the seismic input. The responses in terms of slope acceleration and deformation, earth pressure, pile deformation and bending moment, and the anchor cable axial force are measured. The results have demonstrated that the slope vertical settlements and pile head displacements increase with increasing motion intensity. The maximum acceleration amplification is observed around the pile head, and the accelerations around the bedrock surface are attenuated. The largest dynamic earth pressure occurs at the pile head and then decreases with increasing depth due to the decreased soil-pile relative deformation. The presence of the anchor cable inhibits the build-up of dynamic earth pressure and leads to a negative bending moment. The maximum bending moment appears around the soil-rock interface because of the significant stiffness difference. Experimental results also illustrate that the axial force of the anchor cable is proportional to the pile head deformation. This work provides experimental evidence on the seismic behavior of a slope reinforced by anchored piles and will be beneficial to the calibration of numerical models and design methods.