Selective photothermolysis of lipid‐rich tissues: A free electron laser study
RR Anderson, W Farinelli, H Laubach… - Lasers in Surgery …, 2006 - Wiley Online Library
Lasers in Surgery and Medicine: The Official Journal of the …, 2006•Wiley Online Library
Abstract Background and Objectives In theory, infrared vibrational bands could be used for
selective photothermolysis of lipid‐rich tissues such as fat, sebaceous glands, or
atherosclerotic plaques. Study Design/Materials and Methods Absorption spectra of human
fat were measured, identifying promising bands near 1,210 and 1,720 nm. Photothermal
excitation of porcine fat and dermis were measured with a 3.5–5 µm thermal camera during
exposure to the free electron laser (FEL) at Jefferson National Laboratory. Thermal damage …
selective photothermolysis of lipid‐rich tissues such as fat, sebaceous glands, or
atherosclerotic plaques. Study Design/Materials and Methods Absorption spectra of human
fat were measured, identifying promising bands near 1,210 and 1,720 nm. Photothermal
excitation of porcine fat and dermis were measured with a 3.5–5 µm thermal camera during
exposure to the free electron laser (FEL) at Jefferson National Laboratory. Thermal damage …
Background and Objectives
In theory, infrared vibrational bands could be used for selective photothermolysis of lipid‐rich tissues such as fat, sebaceous glands, or atherosclerotic plaques.
Study Design/Materials and Methods
Absorption spectra of human fat were measured, identifying promising bands near 1,210 and 1,720 nm. Photothermal excitation of porcine fat and dermis were measured with a 3.5–5 µm thermal camera during exposure to the free electron laser (FEL) at Jefferson National Laboratory. Thermal damage to full‐thickness samples exposed at ∼1,210 nm through a cold contact window, was assessed by nitrobluetetrazolium chloride staining in situ and by light microscopy.
Results
Photothermal excitation of fat was twice that of dermis, at lipid absorption bands (1,210, 1,720 nm). At 1,210 nm, a subcutaneous fat layer several mm thick was damaged by FEL exposure, without apparent injury to overlying skin.
Conclusion
Selective photothermal targeting of fatty tissues is feasible using infrared lipid absorption bands. Potential clinical applications are suggested by this FEL study. Lasers Surg. Med. 38:913–919, 2006. © 2006 Wiley‐Liss, Inc.
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