Selective recognition of the di/trimethylammonium motif by an artificial carboxycalixarene receptor
Organic & Biomolecular Chemistry, 2017•pubs.rsc.org
Chemical tools that recognise post-translational modifications have promising applications
in biochemistry and in therapy. We report a simple carboxycalixarene that selectively binds
molecules containing di/trimethylammonium moieties in isolation, in cell lysates and when
incorporated in histone peptides. Our findings reveal the potential of using
carboxycalixarene-based receptors to study epigenetic regulation.
in biochemistry and in therapy. We report a simple carboxycalixarene that selectively binds
molecules containing di/trimethylammonium moieties in isolation, in cell lysates and when
incorporated in histone peptides. Our findings reveal the potential of using
carboxycalixarene-based receptors to study epigenetic regulation.
Chemical tools that recognise post-translational modifications have promising applications in biochemistry and in therapy. We report a simple carboxycalixarene that selectively binds molecules containing di/trimethylammonium moieties in isolation, in cell lysates and when incorporated in histone peptides. Our findings reveal the potential of using carboxycalixarene-based receptors to study epigenetic regulation.
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