This study aimed to assess the effect of distance learning on students' self-directed learning skills and motivation during the lockdown period of the COVID–19 pandemic. The study relies on a quantitative methodology. The data were collected using an administrative online survey distributed to 427 respondents with different majors (BBA) enrolled in the learning skills and scientific research skills course (obligatory course) in the second semester of the academic year 2020/2021 at The University of Jordan. Regression analysis was used to analyze the proposed hypotheses. The results showed that the independent variable (Distance Learning) positively influenced students' motivation and self-directed learning skills. The recommendations based on the outcomes of this research are useful for educational specialists to develop learning environments about the effects of distance learning on students' self-directed learning skills and motivation. In terms of limitations, the analysis was performed in one university only; therefore, attention must be paid when generalizing the results.