(57) ABSTRACT A glucose binding amphiphilic peptide hydrogel insulin delivery system that
is responsive to glucose concentrations under physiological conditions is provided. Insulin is
encapsulated in a glucose binding hydrogel, made from selfassembling amphiphilic
peptides including a hydrophobic domain including a beta sheet forming region coupled to a
charged hydrophilic domain modified to contain a glucose binding segment. The
formulations are designed to release insulin as a function of blood glucose level …