Unravelling innervation of pancreatic islets

RF Hampton, M Jimenez-Gonzalez, SA Stanley - Diabetologia, 2022 - Springer
… In rats, intranodose injection of an anterograde tracer demonstrated vagal sensory innervation
of the islet core, exocrine pancreas, vasculature and major ducts. However, labelled fibres …

Pancreatic β-cells communicate with vagal sensory neurons

M Makhmutova, J Weitz, A Tamayo, E Pereira… - Gastroenterology, 2021 - Elsevier
… We found that pancreatic islets are innervated by vagal sensory axons expressing Phox2b,
substance P, calcitonin-gene related peptide, and the serotonin receptor 5-HT 3 R. Centrally, …

Pancreatic innervation in mouse development and β-cell regeneration

RE Burris, M Hebrok - Neuroscience, 2007 - Elsevier
Islet sensory innervation appears unaffected in RIP-cmyc ER … interruption of sensory
innervation of pancreatic islets was … signaling takes place before pancreatic islets are fully mature, …

A quantitative analysis of the sensory and sympathetic innervation of the mouse pancreas

TH Lindsay, KG Halvorson, CM Peters, JR Ghilardi… - Neuroscience, 2006 - Elsevier
… nerve fibers immunostained for 200 kD neurofilament H (clone RT97) (A) are found near
large blood vessels in the exocrine pancreas, but have minimal association with the islets of …

Optical imaging of pancreatic innervation

M Makhmutova, A Caicedo - Frontiers in Endocrinology, 2021 - frontiersin.org
… branch out to innervate the vasculature, endocrine cells of pancreatic islets, exocrine acini,
sensory fibers project preferentially to pancreatic islets, indicating that the exocrine sensory

Neural regulation of pancreatic islet cell mass and function

B Thorens - Diabetes, Obesity and Metabolism, 2014 - Wiley Online Library
… secretion of glucagon and insulin by pancreatic islet α- and β-… nervous system that richly
innervates this endocrine organ. … system, which richly innervate pancreatic islets to control many …

Deletion of the insulin receptor in sensory neurons increases pancreatic insulin levels

CW Grote, NM Wilson, NK Katz, BL Guilford… - Experimental …, 2018 - Elsevier
… content in the islets of Langerhans of the pancreas. These results … sensory innervation of
pancreatic islets is key to regulating islet function and that a negative feedback loop of sensory

Neural control of the endocrine pancreas

R Rodriguez-Diaz, A Caicedo - Best practice & research Clinical …, 2014 - Elsevier
… In addition to autonomic efferent axons, islets also receive sensory innervation. These … to
stimulate specifically the axons innervating the pancreatic islet. Stimulating the parasympathetic …

The insulin receptor is colocalized with the TRPV1 nociceptive ion channel and neuropeptides in pancreatic spinal and vagal primary sensory neurons

BA Lázár, G Jancsó, O Oszlács, I Nagy, P Sántha - Pancreas, 2018 - journals.lww.com
… , peptidergic primary sensory neurons … pancreatitis. Immunohistochemical studies have also
revealed the coexpression of SP and CGRP with TRPV1 in sensory nerves serving the islets

[HTML][HTML] Sympathetic innervation during development is necessary for pancreatic islet architecture and functional maturation

P Borden, J Houtz, SD Leach, R Kuruvilla - Cell reports, 2013 - cell.com
… By employing genetic and chemical ablation of sympathetic neurons in mice, we show
that sympathetic innervation is necessary for establishing pancreatic islet shape and …