Separating and probing tautomers of protonated nucleobases using differential mobility spectrometry
A Anwar, J Psutka, SWC Walker, T Dieckmann… - International Journal of …, 2018 - Elsevier
The protonated nucleobases (C+ H)+,(T+ H)+,(U+ H)+,(A+ H)+, and (G+ H)+ are investigated
in a combined experimental and computational study using differential mobility spectrometry
(DMS), mass spectrometry, and electronic structure calculations. DMS is used to isolate
individual tautomeric forms for each protonated nucleobase prior to characterization with
HDX or CID. The population distributions of each protonated nucleobase formed by
electrospray ionization (ESI) are dominated by a single tautomeric form, as is predicted by …
in a combined experimental and computational study using differential mobility spectrometry
(DMS), mass spectrometry, and electronic structure calculations. DMS is used to isolate
individual tautomeric forms for each protonated nucleobase prior to characterization with
HDX or CID. The population distributions of each protonated nucleobase formed by
electrospray ionization (ESI) are dominated by a single tautomeric form, as is predicted by …