[HTML][HTML] Sequence alterations in the YBX2 gene are associated with male factor infertility
OBJECTIVE: To investigate YBX2 gene alterations in men with severe defects in
spermatogenesis, including azoospermia or severe oligozoospermia, and protamine
deregulation. MSY2 has been identified as a central component in the regulation of
spermatogenesis in mice, but the potential role of its human orthologue, YBX2 or “Contrin,”
in human infertility is not known. DESIGN: A prospective cohort study. SETTING: University
infertility clinic and associated research laboratory. PATIENT (S): A total of 288 men were …
spermatogenesis, including azoospermia or severe oligozoospermia, and protamine
deregulation. MSY2 has been identified as a central component in the regulation of
spermatogenesis in mice, but the potential role of its human orthologue, YBX2 or “Contrin,”
in human infertility is not known. DESIGN: A prospective cohort study. SETTING: University
infertility clinic and associated research laboratory. PATIENT (S): A total of 288 men were …
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