Dose, exposure time and resolution in serial X-ray crystallography

D Starodub, P Rez, G Hembree, M Howells… - Journal of …, 2008 - journals.iucr.org
X-ray diffraction microscopy is limited by the maximum dose that can be delivered prior to
sample damage. In the proposed serial crystallography … across a continuous X-ray beam, and …

Serial X-ray crystallography

KH Nam - Crystals, 2022 - mdpi.com
… The serial femtosecond crystallography (SFX) technique using an X-ray free electron laser
(XFEL) has now been extended to serial synchrotron crystallography (SSX) using synchrotron …

Serial crystallography for structure-based drug discovery

L Zhu, X Chen, EE Abola, L Jing, W Liu - Trends in pharmacological …, 2020 - cell.com
… Protein X-ray crystallography has proved to be the most effective tool for these studies.
Structure determination at each cycle in the iterative process provides invaluable knowledge to …

Serial synchrotron X-ray crystallography (SSX)

K Diederichs, M Wang - Protein Crystallography: Methods and Protocols, 2017 - Springer
Prompted by methodological advances in measurements with X-ray free electron lasers, it
was realized in the last two years that traditional (or conventional) methods for data collection …

[HTML][HTML] In meso in situ serial X-ray crystallography of soluble and membrane proteins

CY Huang, V Olieric, P Ma, E Panepucci… - … Crystallography, 2015 - scripts.iucr.org
The lipid cubic phase (LCP) continues to grow in popularity as a medium in which to generate
crystals of membrane (and soluble) proteins for high-resolution X-ray crystallographic

Megahertz serial crystallography

MO Wiedorn, D Oberthür, R Bean, R Schubert… - Nature …, 2018 - nature.com
… We demonstrate here that serial femtosecond crystallography using bursts of megahertz
repetition rate X-ray pulses is capable of high-resolution structure determination using high-…

Pink-beam serial crystallography

A Meents, MO Wiedorn, V Srajer, R Henning… - Nature …, 2017 - nature.com
Serial X-ray crystallography allows macromolecular structure determination at both X-ray
The time resolution for serial synchrotron crystallography experiments has been limited to …

Chemical crystallography by serial femtosecond X-ray diffraction

EA Schriber, DW Paley, R Bolotovsky, DJ Rosenberg… - Nature, 2022 - nature.com
X-ray diffraction 2,3 and electron microdiffraction 4,5,6,7,8,9,10,11 . Here we demonstrate
small-molecule serial femtosecond X-ray crystallography (… suspensions to X-ray free-electron …

Sample delivery media for serial crystallography

KH Nam - International Journal of Molecular Sciences, 2019 - mdpi.com
X-ray crystallography at cryogenic temperatures using a single crystal. Serial femtosecond
crystallography … In serial crystallography (SX), one of the most important aspects is the …

[HTML][HTML] Serial synchrotron and XFEL crystallography for studies of metalloprotein catalysis

MA Hough, RL Owen - Current Opinion in Structural Biology, 2021 - Elsevier
X-ray crystallography is the major … serial crystallography can play in understanding
metalloprotein catalysis and the additional insight that methods complementary to the primary X-ray