Seroprevalence of hepatitis C virus antibodies in sickle cell anaemia patients in Benin-City, Nigeria
IA Nwannadi, OO Alao, GN Bazuaye… - Gomal Journal of …, 2012 - gjms.com.pk
Gomal Journal of Medical Sciences, 2012•gjms.com.pk
Background: The rate of blood transfusion is high in Nigeria due to high prevalence of sickle
cell anaemia. Hepatitis C virus infection is a blood borne infectious disease primarily
transmitted parenterally. This study was conducted to see the prevalence of Hepatitis C virus
among patients with sickle cell anemia. Methods: This study was conducted at University of
Benin Teaching Hospital, Edo state, Nigeria, from January 2009 to April 2009. Candidates
for this study were adults> 15 years, from Haematology Out-Patient Department …
cell anaemia. Hepatitis C virus infection is a blood borne infectious disease primarily
transmitted parenterally. This study was conducted to see the prevalence of Hepatitis C virus
among patients with sickle cell anemia. Methods: This study was conducted at University of
Benin Teaching Hospital, Edo state, Nigeria, from January 2009 to April 2009. Candidates
for this study were adults> 15 years, from Haematology Out-Patient Department …
Abstract
Background: The rate of blood transfusion is high in Nigeria due to high prevalence of sickle cell anaemia. Hepatitis C virus infection is a blood borne infectious disease primarily transmitted parenterally. This study was conducted to see the prevalence of Hepatitis C virus among patients with sickle cell anemia.
Methods: This study was conducted at University of Benin Teaching Hospital, Edo state, Nigeria, from January 2009 to April 2009. Candidates for this study were adults> 15 years, from Haematology Out-Patient Department. Haemoglobin phenotype of patients was confirmed by haemoglobin electrophoresis. Blood transfusion history and demographic information were collected. Blood sample was taken from each participant for HCV antibody by enzyme-linked immune-sorbent assay. Data was analyzed using SPSS version 15.
Results: A total of 252 sickle cell anaemia patients were recruited; 200 with history of regular blood transfusions and 52 who never had blood transfusion. They comprised of 56 (22.2%) males and 196 (77.8%) females, with male to female ratio of 1: 3.5. Age range was 15-48 years, mean 26.6±6.0 years. The prevalence of anti-HCV antibodies in sickle cell anaemia with regular blood transfusions was 4.5%(9 out of 200), and it was 1.9%(1 out of 52) in those who never had blood transfusion (p= 0.0001).
Conclusion: The seroprevalence of Hepatitis C virus antibodies among regularly transfused sickle cell anemia patients is significantly higher than those not requiring transfusions.
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