Objective To determine the persistence of bactericidal antibody titres following immunisation
with serogroup C meningococcal glycoconjugate vaccine at age 6-15 years in order to
examine changes in persistence of antibodies with age. Design Observational study. Setting
Secondary and tertiary educational institutions in the United Kingdom. Participants Healthy
adolescents aged 11-20 years previously immunised between 6 and 15 years of age with
one of the three serogroup C meningococcal vaccines. Intervention Serum obtained by …

… In the accompanying study, Snape and colleagues evaluate the persistence of serum
bactericidal antibody against meningococcal serogroup C in a large cohort of adolescents
originally immunised with serogroup C meningococcal conjugate vaccines at 6-15 years of
age.4 These vaccines, now used in many countries, were licensed on the basis of
immunogenicity rather than clinical efficacy.5 Despite the high public profile of … In the United
Kingdom, the public health response to this has been the recent addition of a booster dose …