Serum anion gap predicts lactate poorly, but may be used to identify sepsis patients at risk for death: a cohort study
Purpose (1) To test whether serum bicarbonate or anion gap can be used to predict elevated
lactate or mortality in emergency department (ED) patients with sepsis, and (2) to define
thresholds that may predict elevated lactate and mortality. Methods Retrospective diagnostic-
validation study of adults with sepsis treated in a 60,000-visit Midwestern university ED
(2010–2015). In the derivation sample, 8 experts selected thresholds based on objective
measures to optimize clinical utility. Test performance was reported using likelihood ratios …
lactate or mortality in emergency department (ED) patients with sepsis, and (2) to define
thresholds that may predict elevated lactate and mortality. Methods Retrospective diagnostic-
validation study of adults with sepsis treated in a 60,000-visit Midwestern university ED
(2010–2015). In the derivation sample, 8 experts selected thresholds based on objective
measures to optimize clinical utility. Test performance was reported using likelihood ratios …
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