To evaluate serum VEGF-A levels in squamous cell carcinoma of head and neck (SCCHN) patients and relationships with response to therapy. Serum VEGF-A levels in patients (n= 72) treated with radiotherapy (RT) or radio-chemotherapy (RCT) and controls (n= 40) were measured by ELISA. Serum VEGF-A levels of the SCCHN cases were significantly higher (p= 0.001) than in healthy controls, and in patients with positive as compared to negative lymph node status (p= 0.004). Similarly, patients with advanced stage (Stage III-IV) disease had more greatly elevated levels of serum VEGF-A level than their early stage (Stage I-II) counterparts (p= 0.001). In contrast, there was no significant difference (p= 0.57) in serum level of VEGF-A in patients with advanced T-stage (T3-4) as compared to early stage (T1-2). Similarly, patients with distant metastasis had no significant (p= 0.067) elevation in serum VEGF-A level as compared to non-metastatic disease. However, the non-responder patients had significantly higher serum VEGF-A level as compared to responders (p= 0.001). Our results suggest that the serum VEGF-A level may be a useful biomarker for the prediction of response to therapy in SCCHN.