Severe hypothyroidism caused by hepatic hemangioendothelioma in an infant of a diabetic mother

A Güven, C Aygun, H İnce, M Aydın, FG Pınarlı… - Hormone …, 2005 - karger.com
A Güven, C Aygun, H İnce, M Aydın, FG Pınarlı, K Baysal, S Küçüködük
Hormone research, 2005karger.com
Hemangioendotheliomas can express type 3 iodothyronine deiodinase and cause severe
hypothyroidism. The risk of congenital malformations such as vertebral and cardiac
abnormalities in infants of diabetic mothers is higher than babies of healthy women. Here we
report an infant of a diabetic mother with hypothyroidism caused by liver
hemangioendothelioma. Consumptive hypothyroidism should be an indicator to search for a
vascular tumor in infants. Supranormal doses of L-thyroxine might be required for …
Abstract
Hemangioendotheliomas can express type 3 iodothyronine deiodinase and cause severe hypothyroidism. The risk of congenital malformations such as vertebral and cardiac abnormalities in infants of diabetic mothers is higher than babies of healthy women. Here we report an infant of a diabetic mother with hypothyroidism caused by liver hemangioendothelioma. Consumptive hypothyroidism should be an indicator to search for a vascular tumor in infants. Supranormal doses of L-thyroxine might be required for normalization of thyroid function until the tumor involutes or is resected.
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