… the actions of insulin. Initial research efforts focused on syndromes of severe insulin resistance,
to maximize impact, and also on the search for circulating antibodies against insulin or its …

… those with primary disorders of insulin signaling and those with defects … severe insulin
resistance of both subgroups puts patients at risk of accelerated complications and poses severe …

… understanding of the syndromes associated with severe insulin resistance, much remains to
… defects in insulin signaling responsible for the severe insulin-resistant syndromes remain to …

… of human insulin resistance. Severe insulin resistance syndromes are broadly classified into
three … : lipodystrophies, primary insulin signalling defects or complex syndromes including …

… Although syndromes of severe insulin resistance are commonly diagnosed after -cell
decompensation and the onset of diabetes, they have a range of clinical features which may …

… The Type A syndrome of insulin resistance is the prototypic inherited syndrome of severe
insulin resistance (Table 2). The syndrome is characterized by marked endogenous …

… more severe metabolic decompensation have lower insulin … disease, suggests that insulin
resistance with compensatory … components of the insulin resistance syndrome. Other (prob…

… The rationale for using rhIGF-1 to treat severe insulin resistance syndromes is based on
observations of its direct effects on carbohydrate metabolism. In humans, infusion of rhIGF-1 …

… syndrome caused by mutation of NSMCE2. Each of these commonly feature severely
dyslipidemic insulin resistance. Other extremely rare causes of syndromic severe insulin resistance/…

… Type B insulin resistance syndrome is characterized by severe impairment of … severe
intrauterine growth retardation, type A insulin resistance syndrome and insulin resistance syndrome …