Severe methanol poisoning with neurological sequelae: implications for diagnosis and management

NR Holt, CP Nickson - Internal medicine journal, 2018 - Wiley Online Library
NR Holt, CP Nickson
Internal medicine journal, 2018Wiley Online Library
A 22‐year‐old woman presented with methanol toxicity manifesting as headache, reduced
conscious state and visual change after consuming home‐made grappa. She progressed to
a coma with fixed mydriasis and severe acidaemia (pH 6.55). She was treated with empirical
antidote administration (intravenous ethanol) and enhanced elimination through
haemodialysis. She survived despite her delayed presentation but developed significant
neurological sequelae, including visual impairment. We provide an overview of key …
Abstract
A 22‐year‐old woman presented with methanol toxicity manifesting as headache, reduced conscious state and visual change after consuming home‐made grappa. She progressed to a coma with fixed mydriasis and severe acidaemia (pH 6.55). She was treated with empirical antidote administration (intravenous ethanol) and enhanced elimination through haemodialysis. She survived despite her delayed presentation but developed significant neurological sequelae, including visual impairment. We provide an overview of key elements of diagnosis and recent updates in treatment recommendations.
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