This case report describes the orthodontic treatment of a 20 year-old female who presented with a severe anterior open bite, increased lower facial height and mandibular asymmetry. The patient was diagnosed with a Class I skeletal pattern but a Class III dental relationship, an anterior and unilateral posterior open bite, a canted posterior occlusal plane, a clockwise rotation and vertical growth pattern of the mandible incorporating a chin deviation to the right. The aim of treatment was to correct identified adverse oral habits, improve the facial profile and mandibular asymmetry, provide a satisfactory occlusion and restore TMJ health, which could not be guaranteed. An occlusal splint was used in the first stage of treatment to intrude the posterior teeth, eliminate the occlusal disturbance and control the adverse oral habits. Two micro-implant anchorage devices were placed on the buccal and lingual sides of the left buccal segment to further intrude the left posterior teeth. MEAW technology was used after aligning and levelling the teeth. Satisfactory overbite, overjet and molar relationships were obtained and the facial profile greatly improved after orthodontic treatment, the outcome of which was stable at 24 months’ review.(Aust Orthod J 2017; 33: 258-267)