Sexual minority persons from religious families may experience low acceptance by parents, however, little is known about the relationship of religiosity and parent relationships on mental health into adulthood. This study sought to test a moderated mediation model predicting depression based on religious fundamentalism, parent acceptance, and parent‐child relationship quality. Sexual minority adult participants (n = 384) from across the U.S. completed a web‐based, anonymous survey. Results found a conditional indirect effect of religious fundamentalism on depression through parent acceptance with the parent‐child relationship quality moderating the relationship between parent acceptance and depression. This was significant up to age 52. Clinical implications and future research with sexual minority adults and their families are explored.