Brain functional connectivity mirrors genetic pleiotropy in psychiatric conditions
… genetic overlap (pleiotropy) across psychiatric conditions and … for shared connectivity
profiles across conditions and traits, … risks for psychiatric conditions (ie polygenic scores, PGS). …
profiles across conditions and traits, … risks for psychiatric conditions (ie polygenic scores, PGS). …
Genome-scale transcriptional regulatory network models of psychiatric and neurodegenerative disorders
… transcriptional regulatory proteins may also contribute to disease risk. Both common and
rare genetic variation associated with psychiatric disorders are enriched for genes involved in …
rare genetic variation associated with psychiatric disorders are enriched for genes involved in …
A genome-wide association study for shared risk across major psychiatric disorders in a nation-wide birth cohort implicates fetal neurodevelopment as a key mediator
… the biological substrates mediating this overlap are not well … Recent SNP-based investigations
of shared polygenetic risk … related psychiatric outcomes, true pleiotropy through a parallel …
of shared polygenetic risk … related psychiatric outcomes, true pleiotropy through a parallel …
… sequencing of subgenual anterior cingulate cortex reveals cross-diagnostic and diagnosis-specific RNA expression changes in major psychiatric disorders
…, A Schulmann, W Corona, X Jiang, J Cross… - …, 2021 - nature.com
… revealed that major psychiatric disorders share many common … in mood disorders by
neuroimaging, neuropathology, and … Similarly, we found significant overlap with DE genes …
neuroimaging, neuropathology, and … Similarly, we found significant overlap with DE genes …
The miR-124-AMPAR pathway connects polygenic risks with behavioral changes shared between schizophrenia and bipolar disorder
H Namkung, H Yukitake, D Fukudome, BJ Lee, M Tian… - Neuron, 2023 - cell.com
… and bipolar disorder (BP) are highly heritable major psychiatric disorders that share a substantial
… pathways translate their shared polygenic risks into shared clinical manifestations. This …
… pathways translate their shared polygenic risks into shared clinical manifestations. This …
Convergent molecular, cellular, and cortical neuroimaging signatures of major depressive disorder
… a psychiatric disorder may be particularly vulnerable to illness … (D) Binned analysis revealed
a parallel relationship between … we observed significant enrichment of polygenic depression …
a parallel relationship between … we observed significant enrichment of polygenic depression …
Cortical profiles of numerous psychiatric disorders and normal development share a common pattern
… Given the overlap between PC1 and the numerous other psychiatric and neurological effect
… from late childhood, in parallel with the onset of significant cortical thinning as well as the …
… from late childhood, in parallel with the onset of significant cortical thinning as well as the …
Molecular windows into the human brain for psychiatric disorders
… the underlying neuropathology of psychiatric disorders and … shared and disease-specific
transcriptomic perturbations … to elucidate the functional impact of polygenic risk in SCZ, in which …
transcriptomic perturbations … to elucidate the functional impact of polygenic risk in SCZ, in which …
Consensus molecular environment of schizophrenia risk genes in coexpression networks shifting across age and brain regions
… life genetic risk convergence for psychiatric disorders (28). … postnatal life, perhaps in parallel
to the seminal transition … NC had a relatively low polygenic risk score for SCZ (bottom 37…
to the seminal transition … NC had a relatively low polygenic risk score for SCZ (bottom 37…
Predicting causal genes from psychiatric genome-wide association studies using high-level etiological knowledge
… causal genes across multiple loci based on shared biological … psychiatric disease genes
would likely overlap with known … Leveraging polygenic enrichments of gene features to predict …
would likely overlap with known … Leveraging polygenic enrichments of gene features to predict …