The genetic architecture of bipolar disorder: Entering the road of discoveries

OB Smeland, AJ Forstner, A Charney, EA Stahl… - … Psychiatry, 2020 - Elsevier
Polygenic risk score prediction based on the latest BD … to identify shared and disorder-specific
symptoms based on genetic … found that overlaps between psychiatric disorder expression …

Novel complex interactions between mitochondrial and nuclear DNA in schizophrenia and bipolar disorder

A Schulmann, E Ryu, V Goncalves, B Rollins… - … Psychiatry, 2019 - karger.com
… stratification and polygenic risk scores will test the role of mitochondrial variants in
psychiatric disorders. … disorders parallels polygenic overlap. Science. 2018 Feb;359(6376):693–7. …

The conserved ASTN2/BRINP1 locus at 9q33.1–33.2 is associated with major psychiatric disorders in a large pedigree from Southern Spain

J Pol-Fuster, F Cañellas, L Ruiz-Guerra… - Scientific Reports, 2021 - nature.com
… related-affected subjects would share SNVs and structural variants (… This duplication shares
74.5% overlap with the 3q29 … But since MMDs are polygenic, we obviously cannot search …

Dissecting the genetic overlap of education, socioeconomic status, and mental health

FR Wendt, GA Pathak, T Lencz, JH Krystal, J Gelernter… - medRxiv, 2020 - medrxiv.org
… the genetic risk for psychiatric disorders, personality traits, … Psychiatric disorders were most
sensitive to shared genetic … detection of valid neuroticism polygenic signals. Using a physical …

… systematic analysis of genetically regulated differences in gene expression and the role of co-expression networks across 16 psychiatric disorders and substance use …

ZF Gerring, JG Thorp, ER Gamazon, EM Derks - bioRxiv, 2021 - biorxiv.org
… controls and revealed significant overlap of disease-related … provided important new insights
into the sharing of molecular … , such as a highly polygenic genetic architecture underlying …

Novel disease associations with schizophrenia genetic risk revealed in~ 400,000 UK Biobank participants

R Zhang, A Sjölander, A Ploner, D Lu, CM Bulik… - … psychiatry, 2022 - nature.com
… health conditions predominantly arise due to shared genetic risk or … polygenic risk scores
(PRS) on a broad range of health … problems, including both psychiatric disorders and somatic …

Psychiatric disorders: Grounded in human biology but not natural kinds

SE Hyman - Perspectives in biology and medicine, 2021 - muse.jhu.edu
… of psychiatric disorders are grounded in shared discoverable … grouping separate from the
disorders of neurology, sex endocrinology… psychiatric disorders is highly polygenic and exhibits …

[HTML][HTML] Cross-ancestry, cell-type-informed atlas of gene, isoform, and splicing regulation in the developing human brain

C Wen, M Margolis, R Dai, P Zhang, PF Przytycki… - medRxiv, 2023 - ncbi.nlm.nih.gov
… with neurodevelopmental and psychiatric disorders by large-… are shared, and 2,312/1,891
only have significant genetic … heritable) xQTLs may not overlap strongly with complex traits …

An analysis of genetically regulated gene expression and the role of co-expression networks across 16 psychiatric and substance use phenotypes

ZF Gerring, JG Thorp, ER Gamazon… - European Journal of …, 2022 - nature.com
important new insights into the sharing of molecular mechanisms across mental health
disorders, … Second, it is possible the assumptions of LDSC, such as a highly polygenic genetic …

Genetic variants associated with cross-disorder and disorder-specific risk for psychiatric disorders are enriched at epigenetically active sites in peripheral lymphoid …

ME Lynall, B Soskic, J Hayhurst, J Schwartzentruber… - medRxiv, 2021 - medrxiv.org
… of psychiatric disorders have revealed both shared and specific … Polygenic risk scores (PRS)
for depression, bipolar disorder and … parallel analyses of three “positive control” disorders: …