Helm NB, Padala S, Beck FM, D'Atri AM, Huja SS. Short‐term zoledronic acid reduces
trabecular bone remodeling in dogs. Eur J Oral Sci 2010; 118: 460–465.© 2010 Eur J Oral
Sci The effects of zoledronic acid, a bisphosphonate, on the trabecular bone remodeling
(TBR) of the mandibular condyle are unknown. The objectives of this study were to quantify
and compare TBR in the mandibular condyle and vertebrae of 2‐to 3‐yr‐old dogs and to
evaluate the effects of short‐term zoledronic acid on TBR. Bone samples from two, age …

Objective: Bisphosphonates are widely used to treat diseases of disproportionate bone
resorption; however, possible side-effects include bisphosphonate-related osteonecrosis of
the jaw (BRONJ). The susceptibility of various skeletal sites to BRONJ has been
hypothesized to be related to the level of site-specific bone remodeling. Little is known about
the physiologic trabecular bone remodeling (TBR) in the mandibular condyle of aged dogs
or the effects of bisphosphonates on this TBR. The objectives of this study were to quantify …