Short term methionine restriction increases hepatic global DNA methylation in adult but not young male C57BL/6J mice
Despite well-documented evidence for lifespan extension by methionine restriction (MR),
underlying mechanisms remain unknown. As methionine can alter S-adenosylmethionine
(SAM) and S-adenosylhomocysteine (SAH), the substrate and product of DNA
methyltransferase-1 (DNMT1), we hypothesized that MR diet alters DNA methylation. Young
(8-week-old) and adult (1-year-old) male C57BL/6J mice were fed diets with different levels
of methionine (0.12%-MR, 0.84%-CD) for 12 weeks. Functional indicators of DNA …
underlying mechanisms remain unknown. As methionine can alter S-adenosylmethionine
(SAM) and S-adenosylhomocysteine (SAH), the substrate and product of DNA
methyltransferase-1 (DNMT1), we hypothesized that MR diet alters DNA methylation. Young
(8-week-old) and adult (1-year-old) male C57BL/6J mice were fed diets with different levels
of methionine (0.12%-MR, 0.84%-CD) for 12 weeks. Functional indicators of DNA …
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