Sick Building Syndrome is a term used to describe a situation in which occupants of a building have a symptoms and discomfort. Sick Building Syndrome The symptoms of SBS are shown in complaints that occur in occupants of the building as well as eye irritation, nonspecific symptoms, upper respiratory tract, lower respiratory tract, and skin irritation. SBS was also met on building buildings in schools which caused disruption of teaching and learning activities The method of this study used a literature review which conducted on journals published in the last 10 years with the aim of producing references that are more focused on the development of the latest problems and solutions. The result of this review show that SBS occur because an environment factor, thermal factor, and psychosocial. Overall, this review provides an appropriate reference for further research by the specific factors about SBS and further symptoms related to SBS affect student learning outcomes.