Signal inhibition reveals JAK/STAT3 pathway as critical for bovine inner cell mass development
F Meng, B Forrester-Gauntlett, P Turner… - Biology of …, 2015 - academic.oup.com
The inner cell mass (ICM) of mammalian blastocysts consists of pluripotent epiblast and
hypoblast lineages, which develop into embryonic and extraembryonic tissues, respectively.
We conducted a chemical screen for regulators of epiblast identity in bovine Day 8
blastocysts. From the morula stage onward, in vitro fertilized embryos were cultured in the
presence of cell-permeable small molecules targeting nine principal signaling pathway
components, including TGFbeta1, BMP, EGF, VEGF, PDGF, FGF, cAMP, PI3K, and JAK …
hypoblast lineages, which develop into embryonic and extraembryonic tissues, respectively.
We conducted a chemical screen for regulators of epiblast identity in bovine Day 8
blastocysts. From the morula stage onward, in vitro fertilized embryos were cultured in the
presence of cell-permeable small molecules targeting nine principal signaling pathway
components, including TGFbeta1, BMP, EGF, VEGF, PDGF, FGF, cAMP, PI3K, and JAK …
Signal inhibition reveals JAK/STAT3 pathway as critical for bovine inner cell mass development.
MFL Meng FanLi, B Forrester-Gauntlett, P Turner… - 2015 - cabidigitallibrary.org
The inner cell mass (ICM) of mammalian blastocysts consists of pluripotent epiblast and
hypoblast lineages, which develop into embryonic and extraembryonic tissues, respectively.
We conducted a chemical screen for regulators of epiblast identity in bovine Day 8
blastocysts. From the morula stage onward, in vitro fertilized embryos were cultured in the
presence of cell-permeable small molecules targeting nine principal signaling pathway
components, including TGFbeta1, BMP, EGF, VEGF, PDGF, FGF, cAMP, PI3K, and JAK …
hypoblast lineages, which develop into embryonic and extraembryonic tissues, respectively.
We conducted a chemical screen for regulators of epiblast identity in bovine Day 8
blastocysts. From the morula stage onward, in vitro fertilized embryos were cultured in the
presence of cell-permeable small molecules targeting nine principal signaling pathway
components, including TGFbeta1, BMP, EGF, VEGF, PDGF, FGF, cAMP, PI3K, and JAK …
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