Significant of injectable brucine PEGylated niosomes in treatment of MDA cancer cells
Brucine (BRU) as a natural alkaloid has antitumor, anti-inflammatory and anti-proliferation
activity However; its clinical application is limited due to its low water solubility. The aim of
this study was to increase the therapeutic efficacy of BRU using PEGylated niosomal as
nanocarrier. Here BRU loaded niosomes using different surfactants (Brij 52, Span 60 and
Poloxamer 184) with and without PEG-DSPE were prepared. Niosomes were fabricated with
particle size not exceeding 311 nm and entrapment ranged between 53 and 64%. Total …
activity However; its clinical application is limited due to its low water solubility. The aim of
this study was to increase the therapeutic efficacy of BRU using PEGylated niosomal as
nanocarrier. Here BRU loaded niosomes using different surfactants (Brij 52, Span 60 and
Poloxamer 184) with and without PEG-DSPE were prepared. Niosomes were fabricated with
particle size not exceeding 311 nm and entrapment ranged between 53 and 64%. Total …
Significant of injectable brucine PEGylated niosomes in treatment of MDA cancer cells
HMMM Elnahas - Elsevier, 2022 - publications.zu.edu.eg
Brucine (BRU) as a natural alkaloid has antitumor, anti-inflammatory and anti-proliferation
activity However; its clinical application is limited due to its low water solubility. The aim of
this study was to increase the therapeutic efficacy of BRU using PEGylated niosomal as
nanocarrier. Here BRU loaded niosomes using different surfactants (Brij 52, Span 60 and
Poloxamer 184) with and without PEG-DSPE were prepared. Niosomes were fabricated with
particle size not exceeding 311 nm and entrapment ranged between 53 and 64%. Total …
activity However; its clinical application is limited due to its low water solubility. The aim of
this study was to increase the therapeutic efficacy of BRU using PEGylated niosomal as
nanocarrier. Here BRU loaded niosomes using different surfactants (Brij 52, Span 60 and
Poloxamer 184) with and without PEG-DSPE were prepared. Niosomes were fabricated with
particle size not exceeding 311 nm and entrapment ranged between 53 and 64%. Total …
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