Sildenafil restores cognitive function without affecting β‐amyloid burden in a mouse model of Alzheimer's disease
M Cuadrado‐Tejedor, I Hervias… - British journal of …, 2011 - Wiley Online Library
BACKGROUND AND PURPOSE Inhibitors of phosphodiesterase 5 (PDE5) affect signalling
pathways by elevating cGMP, which is a second messenger involved in processes of
neuroplasticity. In the present study, the effects of the PDE5 inhibitor, sildenafil, on the
pathological features of Alzheimer's disease and on memory‐related behaviour were
investigated. EXPERIMENTAL APPROACH Sildenafil was administered to the Tg2576
transgenic mouse model of Alzheimer's disease and to age‐matched negative littermates …
pathways by elevating cGMP, which is a second messenger involved in processes of
neuroplasticity. In the present study, the effects of the PDE5 inhibitor, sildenafil, on the
pathological features of Alzheimer's disease and on memory‐related behaviour were
investigated. EXPERIMENTAL APPROACH Sildenafil was administered to the Tg2576
transgenic mouse model of Alzheimer's disease and to age‐matched negative littermates …
[引用][C] Sildenafil restores cognitive function without affecting β-amyloid burden in a mouse model of Alzheimer's disease
A Garcia-Osta, N Aguirre, R Franco, C Garcia-Barroso… - 2011 - Wiley-Blackwell
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