Background Lipoapoptosis has been identified as a key event in the progression of
nonalcoholic fatty liver disease (NAFLD), and hence, antiapoptotic agents have been
recommended as a possible effective treatment for nonalcoholic steatohepatitis (NASH).
Silicon, included in meat as a functional ingredient, improves lipoprotein profiles and liver
antioxidant defenses in aged rats fed a high–saturated fat, high-cholesterol diet (HSHCD).
However, to our knowledge, the antiapoptotic effect of this potential functional meat on the …

Silicon included in a restructured meat (RM) matrix (Si-RM) as a functional ingredient has
been demonstrated to be a potential bioactive antidiabetic compound. However, the jejunal
and hepatic molecular mechanisms by which Si-RM exerts its cholesterol-lowering effects
remain unclear. Male Wistar rats fed an RM included in a high-saturated-fat high-cholesterol
diet (HSFHCD) combined with a low dose of streptozotocin plus nicotinamide injection were
used as late-stage type 2 diabetes mellitus (T2DM) model. Si-RM was included into the …