There are a great number of diseases associated with bacteria accumulation on medical devices, which have been studied in the last years. The constant negatives effects that can be produced in human health are a big deal for science. The biomedical investigation is not only concerned to avoid or eliminate the bacteria proliferation but to find materials that present better properties as a benefit for the humans. The ONU proposed focused on raw materials that must be renewables and natural materials. This is following the green chemistry instructions as well as maintaining the world sustainability. Silver is a rare but important element that has been employed for a long period of time as an antimicrobial agent. Based on these principles, its inhibitory activity will depend on the silver form, synthesis, and some other environmental factors such as pH, temperature, among others. This chapter details the synthesis of silver composites based on the combination with a natural or synthetic compound like chitosan, silicon, cotton, polyurethane epoxy, and polyester. The importance of choosing the correct and natural compound, enhancing its properties as well as reducing risks to human health. Thus, silver element can be used in other applications fields like the food industry that also is important for general health.