Simultaneous quantification of ten key Kratom alkaloids in Mitragyna speciosa leaf extracts and commercial products by ultra‐performance liquid chromatography …
Kratom (Mitragyna speciosa) is a psychoactive plant popular in the United States for the self‐
treatment of pain and opioid addiction. For standardization and quality control of raw and
commercial kratom products, an ultra‐performance liquid chromatography− tandem mass
spectrometry (UPLC− MS/MS) method was developed and validated for the quantification of
ten key alkaloids, namely: corynantheidine, corynoxine, corynoxine B, 7‐
hydroxymitragynine, isocorynantheidine, mitragynine, mitraphylline, paynantheine …
treatment of pain and opioid addiction. For standardization and quality control of raw and
commercial kratom products, an ultra‐performance liquid chromatography− tandem mass
spectrometry (UPLC− MS/MS) method was developed and validated for the quantification of
ten key alkaloids, namely: corynantheidine, corynoxine, corynoxine B, 7‐
hydroxymitragynine, isocorynantheidine, mitragynine, mitraphylline, paynantheine …
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