Single-cell transcriptome analysis reveals disease-defining T-cell subsets in the tumor microenvironment of classic Hodgkin lymphoma
T Aoki, LC Chong, K Takata, K Milne, M Hav… - Cancer discovery, 2020 - AACR
Hodgkin lymphoma is characterized by an extensively dominant tumor microenvironment
(TME) composed of different types of noncancerous immune cells with rare malignant cells.
Characterization of the cellular components and their spatial relationship is crucial to
understanding cross-talk and therapeutic targeting in the TME. We performed single-cell
RNA sequencing of more than 127,000 cells from 22 Hodgkin lymphoma tissue specimens
and 5 reactive lymph nodes, profiling for the first time the phenotype of the Hodgkin …
(TME) composed of different types of noncancerous immune cells with rare malignant cells.
Characterization of the cellular components and their spatial relationship is crucial to
understanding cross-talk and therapeutic targeting in the TME. We performed single-cell
RNA sequencing of more than 127,000 cells from 22 Hodgkin lymphoma tissue specimens
and 5 reactive lymph nodes, profiling for the first time the phenotype of the Hodgkin …
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