Singlet oxygen mediated one pot synthesis of N-pyridinylamides via oxidative amidation of aryl alkyl ketones

FA Sofi, R Sharma, SN Kavyasree, SA Salim… - Tetrahedron, 2019 - Elsevier
An environmental friendly, efficient protocol has been realized for the synthesis of N-
pyridinylamides via copper catalyzed oxidative amidation of aryl alkyl ketones with 2-
aminopyridines. This one pot protocol involves chemo selective cleavage of C (O)–C bond
in the presence of singlet oxygen. The reaction conditions are simple, tolerates wide range
of substrates and the products were formed in good to excellent yields. This method offers a
moderate improvement over the earlier successful attempts in generating N-pyridinylamides.
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