Sirtuin 1 attenuates nasal polypogenesis by suppressing epithelial-to-mesenchymal transition
Background Nasal polyps (NPs) imply a refractory clinical course in patients with chronic
rhinosinusitis (CRS). Previously, we showed that hypoxia-inducible factor (HIF) 1 could
mediate nasal polypogenesis through epithelial-to-mesenchymal transition (EMT). Sirtuin 1
(SIRT1), a histone deacetylase, reportedly suppresses the transcriptional activity of HIF-1.
Thus we hypothesized that SIRT1 attenuates nasal polyposis by inhibiting HIF-1–induced
EMT. Objective We sought to determine the role of SIRT1 in patients with nasal polyposis …
rhinosinusitis (CRS). Previously, we showed that hypoxia-inducible factor (HIF) 1 could
mediate nasal polypogenesis through epithelial-to-mesenchymal transition (EMT). Sirtuin 1
(SIRT1), a histone deacetylase, reportedly suppresses the transcriptional activity of HIF-1.
Thus we hypothesized that SIRT1 attenuates nasal polyposis by inhibiting HIF-1–induced
EMT. Objective We sought to determine the role of SIRT1 in patients with nasal polyposis …
以上显示的是最相近的搜索结果。 查看全部搜索结果