… site-specific conjugation method by targeting the native glycosylation site on antibodies as
… The native glycans on Asn-297 of antibodies were enzymatically remodeled in vitro using …

… in conjugation sites and drug‒antibody ratios (DARs). In the past decade, site-specific
conjugation … Normally, synthesis of gsADCs requires antibody glycoengineering with an unnatural …

… site-specific antibody–drug conjugation and marked the beginning of a flurry of activity to
produce site-specific … on glycoengineering make the pendant N-glycans a convenient target for …

… synthesizing antibody-drug conjugates (ADCs) require: 1) site-specific incorporation of the
payload to avoid interference with binding to the target epitope, 2) optimal drug/antibody ratio …

… ) using copper-catalyzed click chemistry yielded a site-specific ADC with a drug-to-antibody …
This ADC was compared with a glycoengineered DAR two site-specific ADC, and both were …

… Here, we devise a novel glycoengineering workflow for the development of site-specific
antibody conjugates. This approach combines metabolic glycoengineering using azido-sugar …

… site-specific antibody–drug conjugates in clinical trials along with the future perspectives of
these site-specific … enzymatic site-specific methods for the conjugation of native antibodies …

… The ADC derived from this antibody by glycoengineering technology involving a mutant
glycosyltransferase and a reactive galactose exhibited specific binding and killing of HER2-…

… of novel glycoengineered therapeutic antibodies with enhanced efficacy, site-specific
antibody–drug conjugation, and site-specific modification of antibodies for fluorescent labeling, …

… This Review discusses the ways mAb glycan residues have been modified for site-specific
linking of cargo molecules and compares this glyco-engineering method with other methods …